Course Title: Biology of Tissue Growth and Repair

Part A: Course Overview

Course Title: Biology of Tissue Growth and Repair

Credit Points: 12.00

Course Code




Learning Mode

Teaching Period(s)


Bundoora Campus


160H Medical Sciences


Sem 2 2006,
Sem 2 2007,
Sem 2 2008,
Sem 2 2009,
Sem 2 2010,
Sem 2 2011,
Sem 2 2012,
Sem 2 2013,
Sem 2 2014,
Sem 2 2015,
Sem 2 2016


Bundoora Campus


160H Medical Sciences


Sem 2 2006,
Sem 2 2007,
Sem 2 2008,
Sem 2 2009,
Sem 2 2010

Course Coordinator: A/Prof Terry Piva

Course Coordinator Phone: +61 3 9925 6503

Course Coordinator Email:

Course Coordinator Location: 223.02.09

Pre-requisite Courses and Assumed Knowledge and Capabilities

BIOL2319 Developmental and Cell Biology and Biochemistry and Molecular Biology 1 (BIOL1177) or equivalent.

Course Description

This course through a series of lectures, tutorials and practicals highlights the current understanding of cellular mechanisms involved in processes such as cell growth and differentiation, cell proliferation and death and their importance in health and disease processes. Emphasis in the lecture component of the course will be on understanding the processes involved and how these relate to diseases such as inflammation and cancer. In the practical component students will study advanced cell biological methods that are currently employed in research and diagnostic laboratories. Analysis of research material will develop the students’ critical thinking in current aspects of tissue dynamics and interactions. The skills developed will be of importance in future study as postgraduate students or employment in research laboratories or industry.

You will gain knowledge in the processes of tissue repair and pathological processes such as inflammation and scarring, immune system function, cancer development, tumour immunology, skin biology, stem cells and embryological development. The practical component will extend your laboratory skills in the area of cell biology techniques such as flow cytometry, western blotting, cell migration, immunohistochemistry and  in situ hybridization.

Objectives/Learning Outcomes/Capability Development

This course contributes to the program learning outcomes in the following disciplines:

Biomedical Science (BP231):

  • Scientific knowledge (PLO2)
  • Inquiry and problem solving (PLO3)
  • Communication skills (PLO4)

Biotechnology/Biomedical Science (BP293):

  • Exhibit depth and breadth of scientific knowledge (PLO2)
  • Critically analyse and solve scientific problems (PLO3)

Course Learning Outcomes
Upon successful completion of this course you should be able to:

  1. Apply understanding of processes involved in normal cell growth and differentiation in embryos, adult tissue and stem cells to analyse the effect of disease on these processes.
  2. Differentiate the roles played by oncogenes and tumor suppressor genes in tumorigenesis
  3. Discuss the effect altered signalling pathways play in tumour cells
  4. Evaluate the role played by stromal cells in cancer cell biology
  5. Identify the protective roles epidermal cells play in skin biology
  6. Distinguish between immune system function in both normal and diseased patients.
  7. Evaluate the mechanisms involved in boosting immune system function in cancer patients
  8. Retrieve and present relevant literature in regards to tumorigenesis, tumour immunology, wound repair and immune system dysfunction

Overview of Learning Activities


Lectures will introduce you to the latest understanding of tissue growth, repair and the factors controlling cell differentiation, proliferation and death. The basis of the techniques used to study these processes will be examined in lectures and tutorials and you will then be able to use some of these techniques in practical classes.

The practical component will include an introduction to techniques used for studying cell growth and tissue repair, including histology, immunohistochemistry, cell signalling and in vitro models of fibroblast and endothelial cell growth and differentiation.

Tutorials are used to discuss the current literature in the areas of cell growth, differentiation and important concepts in the area of repair such as fibrosis, angiogenesis, stem cells as well as cancer development, metastasis and current treatment therapies. Tutorials are designed to assist students in their understanding of material delivered in lectures.

The assignment will be based on current developments in areas of tissue growth and repair as presented in the lectures. This will develop the student’s ability to undertake a research of scientific literature, and will develop their ability to write a report based on this work.

You will undertake the equivalent of two hours per week in lectures plus a total of six tutorial classes of one hour each as well as five practical classes of three hours each. In addition you can expect to spend a minimum of five hours per week in independent study.

Overview of Learning Resources

Learning resources used in this course include text books, lecture notes (PowerPoint presentations), Lectopia recordings of lecture presentations, practical exercises, tutorial classes, and additional references on selected topics. The course site in myRMIT provides opportunities for students to independently access much of this material and use asynchronous discussions as an additional mode of learning.

Overview of Assessment

Assessment involves the following:


Practical reports

Weighting 20%

This assessment task supports CLOs 1, 3, 5, 6 and 8.


Mid-semester test

Weighting 15%

This assessment task supports CLOs 1, 2, 3 and 4.



Weighting 10%

This assessment task supports CLOs 1 to 8.


Tutorial quizzes

Weighting 5%

This assessment task supports CLOs 1 to 7.


End of semester exam

Weighting 50%

This assessment task supports CLOs 1 to 7.


Note that:

 ☒This course has no hurdle requirements.

☐ All hurdle requirements for this course are indicated clearly in the assessment regime that follows, against the relevant assessment task(s) and all have been approved by the College Deputy Pro Vice-Chancellor (Learning & Teaching).