Course Title: Advanced Transfusion and Transplantation Science

Part A: Course Overview

Course Title: Advanced Transfusion and Transplantation Science

Credit Points: 24.00


Course Code




Learning Mode

Teaching Period(s)


Bundoora Campus


160H Medical Sciences


Sem 1 2007,
Sem 1 2008,
Sem 1 2009,
Sem 1 2010,
Sem 1 2011,
Sem 1 2012,
Sem 1 2013,
Sem 1 2014,
Sem 1 2015,
Sem 1 2016


Bundoora Campus


173H School of Health and Biomed


Sem 1 2017,
Sem 1 2018

Course Coordinator: Professor Denise Jackson

Course Coordinator Phone: +61 3 9925 7392

Course Coordinator Email:

Course Coordinator Location: 201.09.013

Course Coordinator Availability: By appointment and following classes

Pre-requisite Courses and Assumed Knowledge and Capabilities

System Enforced Pre-requisites (Enforced by SAMS)




Course Description

This course covers more advanced aspects of the of immune response to blood group and tissue antigens; blood group antigen systems; clinical significance of blood group antigens and antibodies; serological techniques; compatibility testing and procedures; donor selection and testing; blood product preparation, testing and use; transfusion reactions; organ selection and rejection mechanisms.

This course provided more advanced simulations in practical classes using industry technology and blood bank techniques and investigations as a work integrated learning activity.

Objectives/Learning Outcomes/Capability Development

This course contributes to the following Program Learning Outcomes for MC158 Master of Laboratory Medicine:

  • PLO1. Knowledge capability (of  immune response to blood group and tissue antigens in particular HLA; blood group antigen systems including the molecular basis of antigen expression; clinical significance of blood group antigens and antibodies and how this is investigated by in vitro techniques; the immunological principles and methodology of serological techniques; preparation and approval processes for serological reagents; compatibility testing and procedures; donor selection and testing; blood product  preparation, testing and use; transfusion reactions; organ selection and rejection mechanisms).
  • PLO2.  Technical capability (of safe handling of blood for serological investigation of blood group antigens and antibodies; perform from simple to complex antibody investigations; HDFN, AIHA and blood group anomalies.
  • PLO3. Communication skills (in presenting material for laboratory reports,researching the scientific literature and synthesizing information in written reports, participating in on line conferences, oral presentations).
  • PLO4.  Professional work practices (in answering questions on relevant standards of, and regulations governing work practices, conduct of work).
  • PLO5. Reflective practice (in answering case studies and participating in self-directed learning of course content).
  • PLO6. Research capability (critical analysis, problem solving, in participating in problem-based laboratory exercises and case studies involving adverse outcomes in transfusion, haemolytic disease of the foetus and newborn and autoimmune haemolytic disease.



 On successful completion of this course you should be able to:

CLO1.  Be knowledgeable in the discipline of blood transfusion science and its practice in donor services and the hospital/private pathology blood bank environment.

CLO2.  Critically analyse complex clinical cases of blood bank investigations.

CLO3.  Be creative in your problem solving as it relates to blood transfusion.

CLO4.  Discuss ethical and safe practice in the conduct of laboratory investigations.

CLO5.  Compare and contrast international practices in blood transfusion science and solid organ transplantation and place it in a global context.

CLO6.  Discuss the role of the HLA system in immune responses, in solid organ transplantation, extract relevant information and synthesize new communications which conform to the professional guidelines.

Overview of Learning Activities

To achieve the course learning outcomes you will have access to lectures on each of the topics indicated.  Lecture notes will be provided prior to scheduled classes.  Lectures will be recorded allowing you to study the topic content prior to attending the classes.  Lecture times will involve discussion on critical thinking questions and brief tests providing opportunities to review topic content. Socrative interactive quizzes will be run in the lecture for students to gauge their level of knowledge and areas where they need to focus further study.  Tutorials will be conducted on a weekly basis and provide you an opportunity to discuss selected topics in depth.  Most tutorials will consist of selected readings from recent literature and questions to guide the discussion on the topic. Practical sessions will allow you to develop skills in performing a range of serological techniques which will be applied in the investigation of a range of case studies.  Questions will accompany each practical session to assist your critical thinking skills.  A visit to the Red Cross Blood Bank will allow you to see how the theory you have covered in the academic setting is applied in the workplace and to gain an understanding of the practical operation of the Transfusion service.

Over the semester, students will participate and engage in lecture and active learning sessions, practical classes and interactive tutorial workshops.  Independent study will be required during the semester.  

Overview of Learning Resources

The course includes structured theoretical and practical components designed to provide students with comprehensive coverage of the current state of practice in Blood Banking.  The practical program is designed to develop a high level of competence in the performance of laboratory techniques and procedures appropriate to a Hospital Blood Bank.  By structuring most practical classes as problem-solving case-studies, students are encouraged to develop their critical thinking and problem solving skills.  All practical sessions include a range of review questions that cover both the theory and practical material and which form the basis for discussion in post laboratory sessions and through on line conferences.

Assessment activities are conducted as both formative and summative assessment.  Continuous assessment conducted during the semester is reviewed with the class as a whole to ensure that all students are familiar with the course material.  Independent formative assessment material is available to students via the myRMIT.  Lectures will be available as MP3 audio files and screen casts to assist students in their understanding the lecture content.

A visit to the Transfusion Service provides students with exposure to the most up to date information and current practice in Blood Banking and the preparation and use of blood and plasma products.

Overview of Assessment

All hurdle requirements for this course are indicated clearly in the assessment regime that follows, against the relevant assessment task(s) and all have been approved by the College Deputy Pro Vice-Chancellor (Learning & Teaching).


HURDLE: Students need to pass both the theory and practical components of the assessment to PASS the overall course.

Assessment Tasks

Assessment Task 1:  MCQ tests Part 1 and Part 2 - Week 4; Part 1 and Week 9; Part 2

Weighting: 5% each x 4 = 20%

This assessment task supports CLOs 1, 3, 5 & 6

Assessment Task 2:  Tutorial paper - Week 3

Weighting: 10%

This assessment task supports CLOs 1 & 3

Assessment Task 3: Final theory examination

Weighting: 30%

This assessment task supports CLOs 1, 2, 3, 5 & 6

Assessment Task 4: Mid Semester Practical Test

Weighting 10% 

This assessment supports CLOs 2, 3 & 4

Assessment Task 5: Practical Report and in class competency assessment

Weighting 10%

This assessment supports CLOs 2, 3 & 4

Assessment Task 6: Final Practical Exam

Weighting: 20%

This assessment task supports CLOs 2, 3 & 4