Dr Lynn Hodges
School of Health and Biomedical Sciences
+61 3 9925 7038
Science, Engineering and Health
Summary of responsibilities
Dr Hodges is a senior researcher incumbent in the position of Research Scientist for the Natural Products Research Group (NPRG), which is headed by Associate Professor Theo Macrides. The NPRG investigates naturally-derived compounds from plants and marine organisms for bioactivity of therapeutic potential. She is involved in all research areas of the group and is directly responsible for the development of biological assays that are fundamental to the group's research interests.
- PhD (Laboratory Medicine) RMIT University, 2001
- B. App. Sci. (Hons), RMIT University, 1994
- B. App. Sci. (Applied Biology/Biotechnology) RMIT University, 1993
- Cert. App. Sci (Science Laboratory), Preston TAFE, 1986
- Dr Hodges is a casual lecturer, tutor and demonstrator in Biochemistry.
- ONPS2423 Introduction to Medical Biochemistry
- BIOL1177/1181 Biochemistry and Molecular Biology
- BIOL2301/2322 Biomolecules and Cellular Regulation
- ONPS2307 Preclinical Testing
- RADI1127 Nuclear Medicine Methods
- Dr Hodges’ major research project investigates the antiarthritic properties of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. The content and originality of this recent work contributed to the award of a commercial patent to the NPRG research group and the industry partner investigators, McFarlane Marketing (Aust) [Int. Patent Appl. WO2006128244 (Priority Appl. AU 20050902896): A method for the preparation of a lipid extract of mussels by enzymatic-digestion of mussel tissue and recovery of the released lipid fraction].
- Dr Hodges is also actively involved in the investigation of anti-arthritic properties of the plant-derived pentacyclic triterpene lupeol (and its ester derivatives), and of the anti-acne properties of the marine-derived bile alcohol scymnol (and its naturally-occurring sulphate).Dr Hodges is a regular overseer to NPRG Honours and PhD students, having successfully mentored nine honours students and four PhD students in recent times.
Industry / professional / community involvement
- Membership of the Australian Society for Biochemistry and Molecular Biology Inc.
- Membership of the Golden Key National Honour Society.
- Glowacki LL, Hodges LD, Wynne PM, Kalafatis N, Wright PFA, Macrides TA. 2011. Hydroxysteroid dehydrogenase transformations of 5β-scymnol and identification of oxoscymnol transformation products by liquid chromatography–tandem mass spectroscopy. 76, 163-168.
- Muthusamy V, Hodges LD, Macrides TA, Boyle GM, Piva TJ. 2011. Effect of novel marine nutraceuticals on IL-1a-mediated TNF-a release from UVB-irradiated human melanocyte-derived cells. Oxid. Med. Cell Longevity, Article ID 728645, doi:10.1155/2011/728645.
- McPhee S, Hodges LD, Wright PAF, Wynne PM, Kalafatis N, Macrides TA. 2010. Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. Prost. Leuk. Ess. Fatty Acids, 82, 97-103.
- Singh M, Hodges LD, Wright PFA, Chea DMY, Wynne PM, Kalafatis N, Macrides, TA. 2008. The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats. Comp. Biochem. Physiol. Part B. 149, 251-258.
- Treschow AP, Hodges LD, Wright PFA, Wynne PM, Kalafatis N, Macrides TA. 2007. Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp. Biochem. Physiol. Part B. 147, 645-656.
- McPhee S, Hodges LD, Wright PFA, Wynne PM, Kalafatis N, Harney, D, Macrides TA. 2007. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp. Biochem. Physiol. Part B. 146, 346-356.
- Sheean PD, Hodges LD, Kalafatis N, Wright PFA, Wynne PM, Whitehouse MW, Macrides, TA. 2007. Bioactivity of extracts from gonadal tissue of the edible Australian purple sea urchin Heliocidaris erythrogramma. J. Sci. Fd. Agric. 87, 694-701.
- Wyatt RM, Hodges LD, Wright PFA, Wynne PM, Macrides TA. 2005. Phytochemical analysis and biological screening of leaf and twig extracts from Kunzea ericoides. Phytother. Res. 19, 963-970.
- Hodges LD, Macrides TA, Kweifio-Okai G. 2003. Antiprotease effect of anti-inflammatory lupeol esters. Mol. Cell Biochem. 252, 97-101.
- 1996 Australian Society of Biochemistry and Biology Poster Award
- 1995 John Storey Junior Memorial Trust
- 1994 RMIT Research Scholarship with Stipend